Endocrine Abstracts

IntroductionPrimary mediastinal goiter is an extremely uncommon entity. The majority of primary mediastinal goiters were reported as incidental findings on chest imaging of asymptomatic patients. Symptoms related to compression of adjacent structures and hyperthyroidism were rarely described. Herein we report a case of subclinical hyperthyroidism secondary to a primary mediastinal goiter.ObservationA 50 year-...

Hashimoto’s thyroiditis (HT) is a chronic disease that needs a daily substitution by thyroid hormones. The purpose of this study was to assess the level of therapeutic adherence to the hormonal treatment in HT patients and its impact on the thyroid function control.MethodsIt is a cross sectional study including 43 patients treated for hypothyroid Hashimoto’s thyroiditis by levothyroxine (LT4). The patient adherence to tre...

IntroductionGraves orbitopathy is the main extra thyroidal manifestation of Graves’ disease, though severe forms are rare (< 5%). Management of Graves orbitopathy is often suboptimal, largely because available treatments do not target pathogenic mechanisms of the disease. The aim of our study was to evaluate different treatment modalities and assess their impact on the outcome of Graves orbitopathy.Patients and methods...

IntroductionPsychological disorders may be expected in patients with hyperprolactinemia. Indeed, they generally have poor quality of life, anxiety, depression and certain personality troubles. Dopamine agonists are the first-line treatment of prolactinoma. Recently, an increasing number of reports emphasized on dopamine agonists psychological side effects. Effectively, some patients develop de novo psychiatric symptoms or have exacerbation of pre-existin...

Patients with polycystic ovary syndrome (PCOS) have features of the metabolic syndrome, including insulin resistance, obesity, and dyslipidemia, suggesting an increased risk for cardiovascular disease.ObjectiveTo assess the prevalence of metabolic syndrome in patients with a polycystic ovarian sydrome (PCOS).MaterialWe conducted a retrospective study including 51 patients with secondary...

IntroductionThyroid hemiagenesis is defined as the absence of one lobe of the thyroid gland. It represents a rare congenital abnormality with a prevalence of 0.05 to 0.2%. The left lobe is more commonly affected than the right lobe. Thyroid hemiagenesis is incidentally found during a routine thyroid screen. Herein, we report a thyroid hemiagenesis revealed by a compensatory hypertrophy of the contralateral thyroid lobe in an adolescent girl with euthyroi...

IntroductionGraves’ disease is typically characterized by the presence of circulating autoantibodies that stimulate the TSH receptor, inducing hyperthyroidism and goiter. Hashimoto’s thyroiditis is an autoimmune disease leading to thyroid tissue destruction by cell and antibody-mediated immune processes. The development of Hashimoto’s thyroiditis following Graves’ disease is rarely reported. Its pathogenesis is not confirmed. Herein, ...

Introduction: Cardiovascular diseases are frequent in patients with hypopituitarism receiving conventional hormone replacement therapy. They represent the main cause of premature death in this population. Emerging evidence smggests that beyond traditional risk factors, evaluating coronary calcium score (CCS) and inflammatory markers such as high-sensitivity C-reactive protein (hs-CRP) provides valuable insights into cardiovascular health in this population. The aims of the pre...

Introduction: The insulin tolerance test (ITT) is the gold standard for hypothalamic–pituitary adrenal axis assessment. There are different protocols depending on the number and timing of serum samples. Our study aimed to investigate the kinetics of serum glucose and cortisol levels during ITT and to determine the most appropriate times for blood samples.Methods: Our study was cross-sectional and descriptive. One hundred patients with suspected adre...

Introduction: Insulin resistance is classically a feature of type 2 diabetes mellitus (T2D). It may also develop among patients with type 1 diabetes (T1D) increasing the risk of cardiovascular mortality. Metabolic syndrome (MS) reflects a state of IR. The aim of this study was to assess the frequency of MS in a population of young adults with T1D and compare it to healthy controls.Methods: We conducted a case control study including 68 T1D patients and 6...